Actinomycetes

Actinomycetes are group of Gram-positive bacteria. Their GC-rich genomes encode robust biosynthetic potential to produce secondary metabolites of broad structural diversity and commercial importance. Continued exploration of Actinobacteria due to their biotechnological significance has revealed their occurrence in a variety of sources across terrestrial and aquatic ecosystems. My works since 2009 (supported at different levels by UGC and CSIR, Govt. of India) investigated diversity and biosynthetic capabilities of these bacteria from diverse environment types.

1. Microbial Resources: Actinobacteria – a Gift to Mankind

Recognition of novel sources and actinobacterial diversity

2. Uncovering Microbial Space: Omics-guided

Integrated genomic and metabolomic approach to favor natural products discovery

Selected Publications

Cibichakravarthy, B., Jose, P. A.*, 2021. Biosynthetic Potential of Streptomyces Rationalizes Genome-Based Bioprospecting. Antibiotics, 10, 873. [PubMed].

Jose, P. A.*, Maharshi, A., Jha, B., 2021. Actinobacteria in natural products research: Progress and prospects. Microbiological research, 246, 126708. [PubMed].

Sivakala, K.K., Gutiérrez-García, K., Jose, P.A.*, Thinesh, T., Anandham, R., Barona-Gómez, F., & Sivakumar, N., 2021. Desert Environments Facilitate Unique Evolution of Biosynthetic Potential in Streptomyces. Molecules (Basel, Switzerland), 26: 588. [PubMed]

Sivakala K.K., Jose P.A., Anandham., Thinesh, T, Jebakumar, S.R.D., Sivakumar, N., 2018. Spatial physiochemical and metagenomic analysis of desert environment. J. Microbiol. Biotechnol. 28:1517-1526. [PubMed]

Jose P.A.*, Sivakala K.K., Jha B., 2018. Non-Streptomyces actinomycetes and natural products: recent updates, In “Studies in Natural Products Chemistry” Vol. 61, 2018, Pages 395-409. [ScienceDirect]

Masand M, Sivakala KK, Menghani E, Thinesh T, Anandham R, Sharma G, Sivakumar N, Jebakumar SRD and Jose, P.A.*, 2018. Biosynthetic potential of bioactive streptomycetes isolated from arid region of the Thar Desert, Rajasthan (India). Front. Microbiol. 9:687. [PubMed]

Jose, P.A.* and Jha B.*, 2017. Intertidal marine sediment harbours Actinobacteria with promising bioactive and biosynthetic potential. Scientific Reports, 7: 10041. [PubMed]

Jose, P.A.* and Jha B.*, 2016. New dimensions of research on actinomycetes: quest for next generation antibiotics. Frontiers in Microbiology, 7, 01295.
[PubMed]

Masand, M., Jose, P. A.*, Menghani, E. and Jebakumar, S. R. D., 2015. Continuing hunt for endophytic actinomycetes as a source of novel biologically active metabolites. World Journal of Microbiology and Biotechnology, 31: 1863 – 1875. [PubMed]

Rajeswari, , Jose, P. A.^#, Amiya, R. and Jebakumar, S. R. D., 2015. Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity. Frontiers in Microbiology, 5, 753. [PubMed]

Jose, P. A. and Jebakumar, S. R. D., 2014. Unexplored hypersaline habitats are sources of novel actinomycetes. Frontiers in Microbiology 5: 242.
[PubMed]

Jose, P. A. and Jebakumar, S. R. D., 2014. Successive non-statistical and statistical approaches for the improved antibacterial activity of rare actinomycete Nonomuraea JAJ18. BioMed Research International, 2014: 906097. [PubMed]

Jose, P. A. and Jebakumar, S. R. D., 2013. Non-streptomycete actinomycetes nourish the current microbial antibiotic drug discovery. Frontiers in Microbiology 4: 240. [PubMed]

Jose, P. A. and Jebakumar S. R. D., 2013. Diverse Actinomycetes from Indian coastal solar salterns – a resource for antimicrobial screening. Journal of Pure Applied Microbiology 7: 2567-2575.

Jose, P. A., Sivakala, K. K. and Jebakumar, S. R. D., 2013. Formulation and statistical optimization of culture medium for improved production of antimicrobial compound by Streptomyces JAJ06. International Journal of Microbiology 2013: 526260. [PubMed]

Jose, P. A. and Jebakumar, S. R. D., 2013. Phylogenetic appraisal of antagonistic, slow growing actinomycetes isolated from hypersaline inland solar salterns at Sambhar salt Lake, India. Frontiers in Microbiology 4:190.
[PubMed]

Jose, P. A. and Jebakumar, S. R. D., 2012. Phylogenetic diversity of actinomycetes cultured from coastal multipond solar saltern in Tuticorin, India. Aquatic Biosystems, 8: 23. [PubMed]

Jose, P. A., Santhi, V. S. and Jebakumar, S. R. D., 2011. Phylogenetic affiliation, antimicrobial potential and PKS gene sequence analysis of moderately halophilic Streptomyces isolated from an Indian saltpan. Journal of Basic Microbiology, 51: 348-356. [PubMed]